Dexter's Laboratory: Deesaster Strikes! is a platform game for Game Boy Advance featuring Dexter, a boy genius, who faces chaos after his invention, the Clone-a-matic, is sabotaged by his sister Dee Dee. Players guide Dexter through his lab to capture numerous mischievous mini-Dee Dee clones, restore order, and reunite Dee Dee with her original self before their mother arrives.
Dexter has created the ultimate invention - The Clone-a-matic - but his older sister Dee Dee has meddled again and accidentally cloned herself. And, there's not just one of her. Dexter's Laboratory is infested with mini-Dee Dee's bent on destroying Dexter's wonderful experiments - what a nightmare! It's up to players to help Dexter catch the Dee Dee's, put his lab back to normal, and get Dee Dee back to her single self before Mom calls for dinner.