Gremlins: Stripe vs. Gizmo is a platform game for Game Boy Advance featuring two intertwining storylines. Players control either Gizmo, who aims to recover stolen Christmas presents from Stripe and his gremlin allies, or Stripe, who seeks to eliminate Gizmo and conquer the Mogwai. Gameplay involves defeating enemies through various means, depending on the character selected.
In Gizmo's story, the cute Mogwai has to prevent Stripe from ruining Christmas for Kingston Falls by retrieving all the presents that Stripe has stolen. Gizmo uses a flashlight to kill gremlins after rolling into a ball and weakening the gremlins. He also must destroy any gremlins that get in his way. In Stripe's story, he comes up with a scheme to destroy his mortal enemy Gizmo and destroy mogwais.
If playing as Gizmo, all the enemies are generic gremlins. If playing as Stripe, the player will instead fight mogwais.