Serious Sam Advance is a first-person shooter for the Game Boy Advance developed by Croteam and published by Take-Two Interactive. In this installment, the protagonist Sam is sent back to ancient Rome to confront Mental's minions after scientists discover a method to travel through time. The game features ten weapons and a variety of enemies across twelve levels, drawing from previous entries in the series.
Scientists figure out how to use the timelock to send someone to any point in time, Sam travels back to ancient Rome as people haven't been returning from that period and ends up fighting Mental's minions once again.
The game has ten weapons and ten enemies, most of which are taken from the other Serious Sam games. It spans twelve levels.