Rampage 2: Universal Tour is an action-adventure game for the Game Boy Color, featuring three iconic monsters: George, Lizzie, and Ralph. Players control these creatures to demolish buildings, consume civilians, and destroy vehicles in various locations. After rescuing the monsters, they confront an alien invasion, embarking on a journey through space to save Myukus and dismantle the alien bases in the Solar System.
Players choose one of the three original monsters to rescue. The player then uses the characters in the part of the world where the rescue is held. They work as a collective to break buildings, eat people, and destroy cars and this creates competition among players. When a player (literally) unlocks George, Lizzie, or Ralph, then they become playable characters. Once all the monsters are rescued, aliens begin to invade the earth, leaving the monsters the only ones who can save the planet they just helped partially destroy. After fending off the invasion on Earth, the monsters rescue Myukus (a cyclops-like alien) from Area 51 before chasing the aliens through space, destroying the aliens' bases throughout the Solar System and eventually rampaging through their homeworld.