Aero Star is a video game developed for the Game Boy set in a post-apocalyptic Earth following the Sixth World War. In this environment, mutants have thrived while humans attempt to reclaim their former habitat. Players control Aerostar, a lone fighter tasked by the Intergalactic Council to protect humanity's reestablishment and combat mutant threats in the desolate landscape.
After the end of the Sixth World War, the Earth has been rendered inhospitable and uninhabitable by humanity. The Intergalactic Council ruled that Earth could once again be used by humans and sent people there to restore civilization there. Meanwhile, mutants have prospered in the long-lost wastelands of Earth and were unwilling to allow the humans to have it again. The Intergalactic Council has sent in a lone fighter called Aerostar to defend the Earth from a second act of total destruction.