Teenage Mutant Ninja Turtles III: The Manhattan Project is a side-scrolling beat em up game developed for the Nintendo Entertainment System. It builds upon the play mechanics of its predecessor Teenage Mutant Ninja Turtles II: The Arcade Game while offering an original storyline and levels. Players control the Teenage Mutant Ninja Turtles as they combat familiar foes and navigate through Manhattan.
Teenage Mutant Ninja Turtles III: The Manhattan Project is a side-scrolling beat-'em-up. The game features play mechanics similar to the previous game, Teenage Mutant Ninja Turtles II: The Arcade Game, but it is an original title for the NES without any preceding arcade version.