South Park for Nintendo 64 is a single-player action game featuring a story mode divided into five episodes with fifteen levels. Players control four main characters who share a single life bar and use various humorous weapons such as snowballs and cow launchers. The game includes weak minions, sub-bosses, and a final boss encounter. As health decreases, characters become more frustrated, leading to humorous commentary and exaggerated profanity.
Single player takes the form of a `Story` mode divided into five episodes and fifteen linear levels. The player will face weak minions (which change based on the episode), plus occasional sub-bosses which will try to escape into town. The final level is devoted to a unique boss fight. Players use quirky weapons ranging from infinite yellow snowballs to cow launchers and toxic Terrance and Phillip dolls. Every weapon has a secondary fire, and players switch between the four main characters when they switch weapons - each of the four kids shares a single life bar because of this. The kids will comment on game actions as they occur, with heavier profanity censored with bleeps. The kids will get angrier (and fouler) as their health depletes, until they finally give up on saving the town and go home.