Players take the role of George from the popular cartoon show, George of the Jungle, in a 3D side scrolling action-adventure. Players swing, climb, and platform their way through the jungle in search of the missing documents which could hold the key to the `secret` medical mystery. The camera views and turns show the 3D view, but essentially the game is played as a 2D platformer with a linear path on a single plane. Often George needs to manipulate objects in the environment, for instance moving boxes to create a platform, to continue.