Tuff E Nuff is a fighting game for the Super Nintendo set in a post-apocalyptic world. Players can choose from four strong characters who battle each other to challenge a powerful ruler. The gameplay features classic beat 'em up mechanics with punches, kicks, and throws. Matches are best-of-three, with points for hits and victories, and a 90-second timer option that can be enabled or disabled.
Following a great war that destroys most of the earth, Tuff E Nuff sees four of the earth's toughest people come together to do battle, and earn the right to attempt to depose the mighty ruler. Gameplay is standard beat 'em up style action, featuring most of the conventions of the genre. The characters have a range of kicks, punches and throws, and each fight at their own base. The 90-second time limit can be turned on or off. Fights are best-of-three, with points awarded for each hit, and for overall victory.